Role of tissue (type 2) transglutaminase in the pathogenesis and diagnosis of coeliac disease and dermatitis herpetiformis
نویسنده
چکیده
S FORMING THE BASIS OF THIS WORK 1. Sárdy M, Kárpáti S. Comparison of a tissue transglutaminase enzyme-linked immunosorbent assay with the endomysium antibody test in the diagnosis of dermatitis herpetiformis. J Invest Dermatol 1999; 113:448. IF: 4.903 2. Preisz K, Kárpáti S, Sárdy M, Zágoni T, Horváth A. Codistribution of tissue trans-glutaminase and tissue-bound IgA in jejunum of patients with dermatitis herpetiformis. J Invest Dermatol 2000; 115(3):580. IF: 4.539 3. Sárdy M, Csikós M, Geisen C, Preisz K, Tomsits E, Töx U, Wieslander J, Kárpáti S, Paulsson M, Smyth N. Tissue transglutaminase (TGc) is a minor antigen in autoimmune disease independent of gluten sensitive enteropathy. J Invest Dermatol 2001; 117:779. IF: 4.539 (2000) * In 2000, our research group won the scientific award of the GermanHungarian Dermatological Society with this article. PUBLICATIONS ON THE TG RESEARCH BEING IN INDIRECT CONNECTION WITH THIS WORK 1. Sárdy M, Kárpáti S, Merkl B, Paulsson M, Smyth N. Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J Exp Med 2002; 195:747-57. IF: 15.236 (2000) 2. Becker K, Csikós M, Sárdy M, Szalai Zs, Horváth A, Kárpáti S. Identification of two novel nonsense mutations in the transglutaminase 1 gene in a Hungarian patient with congenital ichthyosiform erythroderma. Exp Dermatol. In press. IF: 2.434 (2000)
منابع مشابه
Mutagenesis of the catalytic triad of tissue transglutaminase abrogates coeliac disease serum IgA autoantibody binding.
BACKGROUND AND AIMS Tissue transglutaminase (tTG) is an autoantigen in coeliac disease and the related disorder, dermatitis herpetiformis. The detection of autoantibodies directed against tTG is a highly specific marker of coeliac disease; however, it is unclear if there is a role for these autoantibodies in the disease process. The aim of this study was to investigate whether the catalytic tri...
متن کاملIn vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies.
BACKGROUND IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jejunal antibody reactions. It is not known whether similar binding also occurs in coeliac patients in vivo, and may thereby contribute to disease manifestations. AIMS To investigate intestina...
متن کاملCOELIAC DISEASE Missing endomysial and reticulin binding of coeliac antibodies in transglutaminase 2 knockout tissues
Background: Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. Aims: To evaluate whether antigens other than TG2 contribute to EMA/ARA/JEA reactions. Patients:...
متن کاملSmall bowel transglutaminase 2-specific IgA deposits in dermatitis herpetiformis.
Dermatitis herpetiformis (DH) is an extraintestinal manifestation of coeliac disease. Untreated coeliac disease patients are known to have transglutaminase 2 (TG2)-targeted IgA deposits in the small bowel mucosa. To evaluate whether similar intestinal IgA deposits are also present in DH and whether the deposits disappear with gluten-free diet, 47 untreated and 27 treated DH patients were studie...
متن کاملSMALL INTESTINE In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies
Background: IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jejunal antibody reactions. It is not known whether similar binding also occurs in coeliac patients in vivo, and may thereby contribute to disease manifestations. Aims: To investigate intestina...
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